Published By : 21 Jun 2018 | Published By : QYRESEARCH
The faculty of Medicine and Dentistry at the University of Alberta has made a pioneering discovery by detecting therapeutic agents that can potentially be the key for the prevention of cancer from spreading. These new gene targets are claimed to be able to resist 99.5 percent of cancer metastasis in living cells within a human body.
Metastasis is known to cause nearly 90 percent of death among cancer patients and the researchers have now formulated eleven new ways to substantially negotiate metastasis. In this study, researchers have made use of one of its kind platform using a shell-less avian embryo that enabled them in visualizing how cancer cells are growing and spreading. Using knockout library, a molecular tool to insert short hairpin RNA vectors inside cancer cells, these agents are able to attach with the specific genes in cells and stopped them from activating. The researchers detected that clusters of cancer was formed that was not metastatic in nature.
According to the lead author, Konstantin Stoletov, genes can now be queried and validated for their potential to cause metastasis and eleven such genes have already been discovered. It must be noted that once cancer turns metastatic, it seeds through other parts of the body and the disease proliferates. Hence, a therapeutic agent that can obstruct the progression of cancer can substantially increase the chances of survival for the patients.
Going forward, the team is expected to indulge into human trials. This research has gained funds from the Alberta Cancer Foundation and the Canadian Cancer Society.