Published By : 24 Dec 2018 | Published By : QYRESEARCH
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease in the U.S. And 20 percent of those suffering from NAFLD also have NASH, short for non-alcoholic steatohepatitis. NASH is a more serious type of NAFLD. This is because NASH can devolve into liver cancer, scientifically known as cirrhosis, particularly in those afflicted with type 2 diabetes or obesity. NAFLD can also result in cardiovascular disease.
Now scientists from Keck School of Medicine of University of Southern California have established the connection between high cholesterol and fatty diet and NAFLD. They have found out that such unhealthy diets can cause changes in immune system. This in turn can cause NASH, the more severe form of NAFLD.
No Approved Therapy for NASH So far
Unfortunately, at present there is no therapy approved by the U.S. Food and Drug Administration. And with growing prevalence and burden of healthcare, this is proving to be a major concern.
To stem the health issue, the group of scientists from Keck School of Medicine felt that its most important to understand the causes of progression in non-alcoholic fatty liver diseases. This is the first step in designing successful therapeutics for the malady NASH.
Studies have shown that toxic combination of cholesterol and dietary fat can affect the behavior of a particular type of white blood cell in the liver. It is called macrophages. The study leverages mouse for understanding the debilitating effect on the immune system. It shows how the unhealthy food can eventually cause liver inflammation and scarring typically associated with NASH.