Dual Effect of Aspirin

Published By : 20 Aug 2014 | Published By : QYRESEARCH

Ibuprofen, aspirin and naproxen are examples of anti-inflammatory nonsteroid medicines which work by destroying cyclooxygenase, an enzyme which aids in the production of prostaglandins, lipid compounds with hormone like characteristics which are connected to ailments such as menstrual cramps, wound sepsis, arthritis and headaches. 

According to researchers at the University of California, the popular drug aspirin has a dual effect of not only destroying cyclooxygenase, but also propels this enzyme to release another compound that accelerates the end of inflammation, thereby enabling the cells to return to a state of normal health. Aspirin prevents the production of prostaglandins which is the main cause of pain and inflammation. 

According to a senior author and professor of Pharmacology and Biochemistry, states that a compound called 15-HETE are produced by cyclooxygenase after the effects of aspirin. Another enzyme converts 15-HETE into lipoxin during any kind of inflammation and infection. Lipoxin is known to be reversing the effects of inflammation. 

Researchers have studied the working of macrophages, which are a certain category of white blood cells which act as protectors of the immune system from infection and injury. It was observed that macrophages not only consist of the biochemical components that prevent the onset of inflammation but also promote recuperation from inflammation by secreting 15-HETE which gradually gets converted into lipoxin with increasing inflammation. Inflammation is actually a natural response of the immune system. 

Researchers have also expressed that the current observations may give way to developing newer therapies on anti-inflammation  by introducing  drugs made of lipoxin and related components that promote reduction in inflammation.
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