Rapamycin to Enhance the Efficacy of Brain Tumor Treatments
Published By : 01 Oct 2014 | Published By : QYRESEARCH
Rapamycin is a drug that is taken by patients who have undergone organ transplant. This drug enables their immune systems to accept the newly transplanted organs like the heart and the kidneys. According to latest research studies, Rapamycin could prove to be beneficial to patients suffering from brain tumor by way of giving a boost to the effect of the newly developed immune-based therapies.
After conducting experiments on animals, the researchers at the University of Michigan Medical School concluded that when an immunotherapy approach was supplemented with Rapamycin, the immune system’s response against brain tumor cells was strengthened.
Furthermore, it was also observed that this drug enhanced the memory cells count in the immune system so that the tumor could be attacked by these cells.
In order to make the treatment of brain tumors more effective, the researchers intend to add Rapamycin to the immunotherapy and gene therapy trials. Adding Rapamycin to gene therapy showed that the organism’s ability to mobilize CD8+T immune cells to destroy the tumor cells immediately got enhanced.
This FDA approved drug, Rapamycin exhibits limited side effects in patients who have undergone transplant and other patients who take it to alter their immune response. This drug curbs mTOR, a type of a molecule in cells. The mTOR pathway is used by brain tumor cells to hinder the immune response in patients. This as a result tricks the immune system and continues to grow without giving caution to the body’s T cells about the presence of a foreign body. The cells get unmasked and become prone to attack when mTOR is inhibited with Rapamycin.